Peroxidase-catalysed metabolism of drugs and carcinogens.
نویسندگان
چکیده
Fig. 3. Effect of inhibition of harmol sulphation by 2,6dichloro-4-nitrophenol ( D C N P ) on the excretion of harmol glucuronide (hg) and harmol sulphate (hs ) Harmol was infused at a rate of 0.76pmol/min after an intravenous loading dose of 4.8pmol. Bile and urine were collected as indicated by the mid-point of each collection period, and in each fraction harmol glucuronide and harmol sulphate were determined. After 2 h an intravenous injection of DCNP (26pmol/kg) was given. M e a n s k s . ~ . are given for five rats; the body weight of the rats was about 300g each.
منابع مشابه
Glutathione S-transferase in humans in health and disease.
Most biological processes are catalysed by means of enzymes and study of these in health and disease is important for our understanding of both biology and disturbed function. The glutathione S-transferases (GST:E.C.2.5.1.18) are a complex multigene family of enzymes that are widely distributed in the animal kingdom. ' These enzymes possess many biological functions, the most important of which...
متن کاملImplications for therapy of drug-metabolizing enzymes in human colon cancer.
Human colonic tissue is exposed to a variety of toxic chemicals and potential carcinogens in the diet and the intestinal microenvironment. Colonic adenocarcinoma is commonly resistant to the cytotoxic effects of most chemotherapeutic drugs. We have examined drug metabolic and detoxification pathways in clinical specimens of colon carcinoma and normal adjacent mucosa from 17 patients. All elemen...
متن کاملThe influence of non-steroidal anti-inflammatory and antithyroid agents on myeloperoxidase-catalysed activities of human leucocytes.
Viable leucocytes obtained fresh from normal human subjects were shown to be able to catalyse the in vitro iodination of bovine serum albumin (BSA) in a H2O2-generating system. The rate and degree of iodination were greatly improved by sonication of the cells. A balanced salt solution was a more favourable medium than phosphate buffer for the myeloperoxidase (MPO)-catalysed iodination of whole ...
متن کاملProstaglandin hydroperoxidase-catalyzed activation of certain N-substituted aryl renal and bladder carcinogens
Certain carcinogens are thought to induce renal and bladder cancer following metabolic activation. We propose a model system for this activation and provide supporting experimental evidence. This model proposes that renal and bladder carcinogens' entry into the urinary tract is facilitated, that carcinogens are activated by the prostaglandin hydroperoxidase activity of prostaglandin endoperoxid...
متن کاملEfficient CeO2 nanoparticles catalysed for Synthesis of heterocyclic Bis(Indolyl) methanes under mild conditions
There is need to develop simple, efficient & economically viable chemical pathways to synthesise biologically active & commercially important heterocyclic Bis(indolyl) methanes1.The indole ring is an important constituent of many natural products, pharmaceuticals & other compounds of commercial importantance2. The literature survey shows that Bis(indolyl) methanes are know...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Biochemical Society transactions
دوره 12 1 شماره
صفحات -
تاریخ انتشار 1984